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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/53721

    Title: Formation of microporous poly(hydroxybutyric acid) membranes for culture of osteoblast and fibroblast
    Authors: Huag, Han-Shiang;Chou, Shiu-Huey;Don, Trong-Ming;Lai, Wei-Chi;Cheng, Liao-Ping
    Contributors: 淡江大學化學工程與材料工程學系
    Keywords: microporous membrane;poly(hydroxybutyric acid);hFOB1.19 cell;L929 cell
    Date: 2009-12
    Issue Date: 2011-05-20 09:56:51 (UTC+8)
    Publisher: Chichester: John Wiley & Sons Ltd.
    Abstract: Microporous membranes of a biodegradable polymer, poly(hydroxybutyric acid) (PHB), were prepared by a phase-inversion process and their cell compatibility was evaluated in vitro. A ternary system, ethanol/chloroform/PHB, was employed to prepare the membranes, wherein ethanol and chloroform were served as the nonsolvent and solvent for PHB, respectively. In the phase-inversion process, the polymer dissolution temperature was varied from 80 to 120°C to yield membranes with specific morphologies, such as globular particles, porous channels, etc. Moreover, cell viability was examined on the formed membranes. Two cell lines, osteoblast hFOB1.19 and fibroblast L929, were cultured in vitro. It was found that these two types of cells exhibited different responses on different membranes: the hFOB1.19 cells showed significant increase in cell proliferation with increase in surface roughness, whereas the L929 cells demonstrated an opposite trend, preferring to attach and grow on a flat surface. PHB membranes with different morphologies exhibit different cell compatibilities, which may be useful means for the architectural design of materials for tissue engineering.
    Relation: Polymers for Advanced Technologies 20(12), pp.1082-1090
    DOI: 10.1002/pat.1366
    Appears in Collections:[Graduate Institute & Department of Chemical and Materials Engineering] Journal Article

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