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https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/53721
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| 题名: | Formation of microporous poly(hydroxybutyric acid) membranes for culture of osteoblast and fibroblast |
| 作者: | Huag, Han-Shiang;Chou, Shiu-Huey;Don, Trong-Ming;Lai, Wei-Chi;Cheng, Liao-Ping |
| 贡献者: | 淡江大學化學工程與材料工程學系 |
| 关键词: | microporous membrane;poly(hydroxybutyric acid);hFOB1.19 cell;L929 cell |
| 日期: | 2009-12 |
| 上传时间: | 2011-05-20 09:56:51 (UTC+8) |
| 出版者: | Chichester: John Wiley & Sons Ltd. |
| 摘要: | Microporous membranes of a biodegradable polymer, poly(hydroxybutyric acid) (PHB), were prepared by a phase-inversion process and their cell compatibility was evaluated in vitro. A ternary system, ethanol/chloroform/PHB, was employed to prepare the membranes, wherein ethanol and chloroform were served as the nonsolvent and solvent for PHB, respectively. In the phase-inversion process, the polymer dissolution temperature was varied from 80 to 120°C to yield membranes with specific morphologies, such as globular particles, porous channels, etc. Moreover, cell viability was examined on the formed membranes. Two cell lines, osteoblast hFOB1.19 and fibroblast L929, were cultured in vitro. It was found that these two types of cells exhibited different responses on different membranes: the hFOB1.19 cells showed significant increase in cell proliferation with increase in surface roughness, whereas the L929 cells demonstrated an opposite trend, preferring to attach and grow on a flat surface. PHB membranes with different morphologies exhibit different cell compatibilities, which may be useful means for the architectural design of materials for tissue engineering. |
| 關聯: | Polymers for Advanced Technologies 20(12), pp.1082-1090 |
| DOI: | 10.1002/pat.1366 |
| 显示于类别: | [化學工程與材料工程學系暨研究所] 期刊論文
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