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    題名: Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
    作者: Jiang, Shih-sheng;Chang, I-shou;Huang, Lin-wei;Chen, Po-cheng;Wen, Chi-chung;Liu, Shu-chen;Chien, Li-chu;Lin, Chung-yen;Hsiung, Chao A.;Juang, Jyh-lyh
    貢獻者: 淡江大學數學學系
    日期: 2006-09-01
    上傳時間: 2011-05-20 09:42:45 (UTC+8)
    出版者: American Society for Microbiology
    摘要: Baculoviruses, a family of large, rod-shaped viruses that mainly infect lepidopteran insects, have been widely used to transduce various cells for exogenous gene expression. Nonetheless, how a virus controls its transcription program in cells is poorly understood. With a custom-made baculovirus DNA microarray, we investigated the recombinant Autographa californica multiple nucleopolyhedrosis virus (AcMNPV) gene expression program in lepidopteran Sf21 cells over the time course of infection. Our analysis of transcription kinetics in the cells uncovered sequential viral gene expression patterns possibly regulated by different mechanisms during different phases of infection. To gain further insight into the regulatory network, we investigated the transcription program of a mutant virus deficient in an early transactivator (pe38) and uncovered several pe38-dependent and pe38-independent genes. This study of baculovirus dynamic transcription programs in different virus genetic backgrounds provides new molecular insights into how gene expression in viruses is regulated.
    關聯: Journal of Virology 80(18), pp.8989-8999
    DOI: 10.1128/JVI.01158-06
    顯示於類別:[數學學系暨研究所] 期刊論文

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