English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 52052/87180 (60%)
造訪人次 : 8894275      線上人數 : 55
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/53533

    題名: Profiling time course expression of virus genes - An illustration of Bayesian inference under shape restrictions
    作者: Chien, Li-Chu;Chang, I-Shou;Jiang, Shih-Sheng;Gupta, Pramod K.;Wen, Chi-Chung;Wu, Yuh-Jenn;Hsiung, Chao A.
    貢獻者: 淡江大學數學學系
    關鍵詞: Baculovirus;Bernstein polynomials;genome-wide expression profile;Markov chain Monte Carlo;microarray experiments;shape restricted regression
    日期: 2009-12
    上傳時間: 2011-05-20 09:42:28 (UTC+8)
    出版者: Beachwood: Institute of Mathematical Statistics
    摘要: There have been several studies of the genome-wide temporal transcriptional program of viruses, based on microarray experiments, which are generally useful in the construction of gene regulation network. It seems that biological interpretations in these studies are directly based on the normalized data and some crude statistics, which provide rough estimates of limited features of the profile and may incur biases. This paper introduces a hierarchical Bayesian shape restricted regression method for making inference on the time course expression of virus genes. Estimates of many salient features of the expression profile like onset time, inflection point, maximum value, time to maximum value, area under curve, etc. can be obtained immediately by this method. Applying this method to a baculovirus microarray time course expression data set, we indicate that many biological questions can be formulated quantitatively and we are able to offer insights into the baculovirus biology.
    關聯: The Annals of Applied Statistics 3(4), pp.1542-1565
    DOI: 10.1214/09-AOAS258
    顯示於類別:[數學學系暨研究所] 期刊論文


    檔案 描述 大小格式瀏覽次數
    1932-6157_3(4)_p1542-1565.pdf469KbAdobe PDF288檢視/開啟



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋