English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 49378/84106 (59%)
造訪人次 : 7367585      線上人數 : 48
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/53089

    題名: The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells
    作者: Chen, Ying-Chieh;Lee, Don-Ching;Hsiao, Chao-Yang;Chung, Yu-Fen;Chen, Huang-Chin;Joseph P. Thomas;Pong, Way-Faung;Tai, Nyan-Hwa;Lin, I-Nan;Chiu, Ing-Ming
    貢獻者: 淡江大學物理學系
    關鍵詞: Neural stem cells;Neural differentiation;Ultra-nanocrystalline diamond;ECM
    日期: 2009-07
    上傳時間: 2010-12-23 13:55:46 (UTC+8)
    出版者: Amsterdam: Elsevier BV
    摘要: The interaction of ultra-nanocrystalline diamond (UNCD) with neural stem cells (NSCs) has been studied along with its surface modification in order to improve its function as a biomaterial. Hydrogen- and oxygen-terminated UNCD films were compared with standard grade polystyrene in terms of their impact on the growth, expansion and differentiation of NSCs. When NSCs were cultured on these substrates in low serum and without any differentiating factors, hydrogen-terminated UNCD films spontaneously induced cell proliferation and neuronal differentiation. Oxygen-terminated UNCD films were also shown to further improve neural differentiation, with a preference to differentiate into oligodendrocytes. Hence, controlling the surface properties of UNCD could manipulate the differentiation of NSCs for different biomedical applications. These observations raise the potential for the use of UNCD as a biomaterial for central nervous system transplantation and tissue engineering.
    關聯: Biomaterials 30(20), pp.3428-3435
    DOI: 10.1016/j.biomaterials.2009.03.058
    顯示於類別:[物理學系暨研究所] 期刊論文


    檔案 描述 大小格式瀏覽次數
    0142-9612_30(20)p3428-3435.pdf967KbAdobe PDF1檢視/開啟



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋