淡江大學機構典藏:Item 987654321/52078
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    題名: 半母數迴歸模型對多變量區間設限資料分析
    其他題名: A semiparametric regression model of multivariate interval-censored data
    作者: 林建宏;Lin, Chien-hung
    貢獻者: 淡江大學統計學系碩士班
    陳蔓樺;Chen, Man-hua
    關鍵詞: 多變量區間設限;比例風險脆弱模型;EM演算法;Multivariate interval-censored;Propotional hazard frailty model;EM algorithm
    日期: 2010
    上傳時間: 2010-09-23 16:41:25 (UTC+8)
    摘要: 右設限失效時間資料的分析方法在過去三十年間已發展的非常完善,隨著發展生物醫學研究,在醫療後續研究中一般所遇到的資料為區間設限資料,例如我們對病患定期調查或觀察,因此真實的失效時間也許未能準確觀察,我們只知道會在某些時間區間當中。
    另一個在分析上所遇到的問題為多變量區間設限失效時間資料,我們所感興趣的失效時間不只一個,且每個失效時間中有相關性的存在。本篇論文考慮使用脆弱模型(frailty model)分析多變量區間設限失效時間資料,使用EM演算法(EM algorithm)估計其迴歸參數,並透過模擬驗證之。
    A voluminous literature on right-censored failure time data has been developed very well in the pust 30 years. Due to advances in biomedical research, interval censoring has become common in medical follow-up studies. For example, each study subject is observed periodically, thus the observed failure time falls into a time period.
    Another problems is multivariate interval-censored failure time data. Multivariate failure time data occur when one is interested in several related failure times. This thesis considers regression analysis of multivariate interval-censored failure time data using by the random effect
    approach. For estimation, an Expectation Maximization (EM) algorithm is developed and simulation studies suggest that the frailty model approach.
    顯示於類別:[統計學系暨研究所] 學位論文

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