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    Title: 尿素酶關聯鎳(II)錯合物之合成、構造、磁性與尿素酶抑制性研究
    Other Titles: The study of model urease correlated Ni(II) complexes : synthesis, structure, magnetic properties, and inhibitions of urease
    Authors: 賴俊鵬;Lai, Chung-peng
    Contributors: 淡江大學化學學系碩士班
    魏和祥;Wei, Ho-hsiang
    Keywords: 尿素;尿素酶;鎳二價錯合物;X光繞射結構;抑制率;IC50;磁性;Urease;Urea;Nickel(II) complexes;X-ray structure;Inhibitory;IC50;Magnetic Properties
    Date: 2010
    Issue Date: 2010-09-23 16:10:50 (UTC+8)
    Abstract:   本論文合成一系列尿素酶模型鎳(II)錯合物且性質由X-ray單晶繞射儀、紅外線光譜、元素分析儀及酵素免疫分析法來分析。
      尿素酶模型鎳(II)錯合物:
    (1) [Ni4(L1)4(H2O)4](DMF)3
    (2) [Ni(2,6-pdca)2Ni(H2O)5](H2O)2
    (3) [Ni(2,6-pdca)2Na2(H2O)5]n
    (4) [Ni(μ1,5-dca)2(DMF)2]n
        H2L1 : 2-(3-methoxy-salicylideneamino)-benzyl-alcohol
        2,6-pdca : 2,6-pyridinedicarboxylic acid
        dca : sodium dicyanoamide
      其中錯合物1, 2, 3和4分別為四核、雙核、二維及一維結構。加入尿素、尿素酶與尿素酶模型鎳(II)錯合物反應,可藉由酵素免疫分析法來分析其抑制性,進而計算其IC50,並藉由SQUID變溫磁化率的測定,了解鎳與鎳之間配位立體結構與磁性行為的關聯性。
    A seiries nickel(II) complexes as functional model compounds were synthesized and characterized by X-ray single crystal diffraction, Infrared spectroscopy, element analyzer, and enzyme-linked immunosorbant assay.

    Nickel(II) complexes :
    (1) [Ni4(L1)4(H2O)4](DMF)3
    (2) [Ni(2,6-pdca)2Ni(H2O)5](H2O)2
    (3) [Ni(2,6-pdca)2Na2(H2O)5]n
    (4) [Ni(μ1,5-dca)2(DMF)2]n
        H2L1 : 2-(3-methoxy-salicylideneamino)-benzyl-alcohol
        2,6-pdca : 2,6-pyridinedicarboxylic acid
        dca : sodium dicyanoamide

    There are found that complexes 1, 2, 3 and 4 are trteanuclear, dinuclear, 2-D and 1-D network structures, respectively. Use the enzyme-linked immunosorbant assay, we can understand the nickel(II) complexes whether have urease inhibitory. Magnetic susceptibilities were measured to understand magnetic behavior of these complexes.
    Appears in Collections:[化學學系暨研究所] 學位論文

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