Attachment of tumor cells to the micropatterns of glutaraldehyde (GA)-crosslinked gelatin

機構典藏 > College of Engineering > Graduate Institute & Department of Mechanical and Electro-Mechanical Engineering > Journal Article > Item 987654321/50719

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Title:	Attachment of tumor cells to the micropatterns of glutaraldehyde (GA)-crosslinked gelatin
Authors:	Ou, Yu-cheng;Hsu, Chih-wen;楊龍杰;Yang, Lung-jieh;Han, Hsieh-cheng;Liu, Yi-wen;Chen, Chien-yuan
Contributors:	淡江大學機械與機電工程學系
Keywords:	gelatin;glutaraldehyde;tumor cells;attachment
Date:	2008
Issue Date:	2010-08-10 15:25:24 (UTC+8)
Publisher:	Scientific Publishing Division Myu
Abstract:	In this work, we propose a novel technique for inducing the attachment of tumor cells to the micropatterns of glutaraldehyde (GA)-crosslinked gelatin. It provides another method to crosslink gelatin other than using photosensitizing agents or selective GA crosslink techniques. This novel technique can ensure the degree of crosslink, prevent an over-crosslink from pattern deformation and enhance the adhesion between gelatin and a glass slide. The best spatial resolution of micro-gelatin bases can be 2 μm. The micropatterns of GA-crosslinked gelatin can still be formed successfully by conventional photolithography. The much less toxic and more biocompatible approaches of strengthening gelatin microstructures can be developed according to the idea herein.
Relation:	Sensors and Materials 20(8), pp.435-446
Appears in Collections:	[Graduate Institute & Department of Mechanical and Electro-Mechanical Engineering] Journal Article

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