English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 49378/84106 (59%)
造訪人次 : 7362992      線上人數 : 64
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/50362


    題名: Synthesis of 2-styrylchromones as a novel class of antiproliferative agents targeting carcinoma cells
    作者: 蕭永政;Shaw, Arthur Y.;Chang, Chun-yi;Liau, Hao-han;Lu, Pei-jung;Chen, Hui-ling;Yang, Chia-ning;Li, Hao-yi
    貢獻者: 淡江大學化學學系
    日期: 2009-06
    上傳時間: 2010-08-09 15:51:33 (UTC+8)
    出版者: Elsevier
    摘要: A series of 2-styrylchromone analogs were synthesized and examined for their antiproliferative effects on a panel of carcinoma cells. Among the tested agents, only 4m exhibited a moderate activity with an IC50 value of 28.9 μM against PC-3 cells which indicates the selectivity of PC-3 cells in response to 2-styrylchromones. In addition, 4q demonstrated the most antiproliferative effect with an IC50 value of 4.9 μM against HeLa cells. Flow cytometric analysis and DAPI staining revealed that HeLa cells exposed to 4q as low as 5 μM induced cell death through sub-G1 arrest and DNA fragmentation. Furthermore, CoMFA analysis of tested 2-styrylchromones resulted in a q2 of 0.459 to generate a 3D-QSAR model on BT483 cell line. Together, these results suggest a potential structural optimization and pharmacological study of 2-styrylchromones.
    關聯: European Journal of Medicinal Chemistry 44(6), pp.2552-2562
    DOI: 10.1016/j.ejmech.2009.01.034
    顯示於類別:[化學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 大小格式瀏覽次數
    0223-5234_44(6)p2552-2562.pdf1330KbAdobe PDF244檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋