Microwave-Assisted Base-Catalyzed Cyclization and Nucleophilic Substitution of O-Azidobenzanilides to Synthesize 1,2-Disubstituted Indazol-3-ones

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/50361

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Title:	Microwave-Assisted Base-Catalyzed Cyclization and Nucleophilic Substitution of O-Azidobenzanilides to Synthesize 1,2-Disubstituted Indazol-3-ones
Authors:	蕭永政;Shaw, Arthur Y.;Chen, Yi-ru;Tsai, Chia-hua
Contributors:	淡江大學化學學系
Keywords:	Base-catalyzed cyclization;indazol-3-one;microwave-assisted
Date:	2009-01-01
Issue Date:	2010-08-09 15:51:06 (UTC+8)
Publisher:	Taylor & Francis
Abstract:	A series of 1,2-disubstituted indazol-3-ones were synthesized by microwave-assisted base-catalyzed cyclization and nucleophilic substitution of o-azidobenzanilides. Among five tested reaction conditions, the cyclization of o-azidobenzanilides catalyzed by sodium hydride in DMF, sequentially followed by the nucleophilic substitution under microwave irradiation, exhibited the optimal results. Moreover, compared to the counterparts prepared by conventional heat, this method demonstrated a more expeditious and efficient process to establish a diversified 1,2-disubstituted indazol-3-one library for high-throughput biological screening.
Relation:	Synthetic Communications 39(15), pp.2647-2663
DOI:	10.1080/00397910802663386
Appears in Collections:	[化學學系暨研究所] 期刊論文

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