English  |  正體中文  |  简体中文  |  Items with full text/Total items : 58667/92377 (64%)
Visitors : 579619      Online Users : 54
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/50361


    Title: Microwave-Assisted Base-Catalyzed Cyclization and Nucleophilic Substitution of O-Azidobenzanilides to Synthesize 1,2-Disubstituted Indazol-3-ones
    Authors: 蕭永政;Shaw, Arthur Y.;Chen, Yi-ru;Tsai, Chia-hua
    Contributors: 淡江大學化學學系
    Keywords: Base-catalyzed cyclization;indazol-3-one;microwave-assisted
    Date: 2009-01-01
    Issue Date: 2010-08-09 15:51:06 (UTC+8)
    Publisher: Taylor & Francis
    Abstract: A series of 1,2-disubstituted indazol-3-ones were synthesized by microwave-assisted base-catalyzed cyclization and nucleophilic substitution of o-azidobenzanilides. Among five tested reaction conditions, the cyclization of o-azidobenzanilides catalyzed by sodium hydride in DMF, sequentially followed by the nucleophilic substitution under microwave irradiation, exhibited the optimal results. Moreover, compared to the counterparts prepared by conventional heat, this method demonstrated a more expeditious and efficient process to establish a diversified 1,2-disubstituted indazol-3-one library for high-throughput biological screening.
    Relation: Synthetic Communications 39(15), pp.2647-2663
    DOI: 10.1080/00397910802663386
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

    Files in This Item:

    File Description SizeFormat
    0039-7911_39(15)p2647-2663.pdf257KbAdobe PDF261View/Open
    Microwave-Assisted Base-Catalyzed Cyclization and Nucleophilic Substitution of O-Azidobenzanilides to Synthesize 1,2-Disubstituted Indazol-3-ones.pdf423KbAdobe PDF0View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback