A reevaluation and discussion on the threshold limit for hemolysis in a turbulent shear flow

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Title:	A reevaluation and discussion on the threshold limit for hemolysis in a turbulent shear flow
Authors:	盧博堅;Lu, Po-chien;Lai, Ho-cheng;劉佳興;Liu, Jia-Shing
Contributors:	淡江大學水資源及環境工程學系
Date:	2001-10-01
Issue Date:	2010-03-26 16:58:06 (UTC+8)
Publisher:	Elsevier
Abstract:	One major factor of red blood cell damage induced by artificial heart valves is the magnitude of turbulent shear stresses in the flow field. An often-cited threshold for hemolysis is 400 N/m2 (Sallam and Hwang, Biorheology 21 (1984) 783). This value, however, was measured with a one-component laser Doppler anemometer and was not calculated from the major principal Reynolds shear stress, therefore underestimatng the threshold. This study performed flow field measurements under similar conditions, using a two-component laser Doppler anemometer and determining major principal Reynolds shear stress, to reevaluate the hemolytic threshold as 800 N/m2 with an exposure time of 1 ms. The Kolmogorov length scales, approximately 9 μm, are capable of inflicting direct damage to the red blood cells. These results will serve as a more accurate reference in future heart valve design and testing.
Relation:	Journal of biomechanics 34(10), pp.1361-1364
DOI:	10.1016/S0021-9290(01)00084-7
Appears in Collections:	[Graduate Institute & Department of Water Resources and Environmental Engineering] Journal Article

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