Effect of Medium on the Permeation of Drugs Through Polymeric Membranes: Competition between Swelling and Partition

淡江大學機構典藏 > 工學院 > 化學工程與材料工程學系暨研究所 > 期刊論文 > Item 987654321/44151

請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/44151

題名:	Effect of Medium on the Permeation of Drugs Through Polymeric Membranes: Competition between Swelling and Partition
其他題名:	溶媒對藥物透過高分子膜之影響: 膨潤效應與分配效應之競爭
作者:	王大銘;葉秀敏;賴君義
貢獻者:	淡江大學化學工程與材料工程學系
關鍵詞:	SWOLLEN MEMBRANES;SOLUTE DIFFUSION;BENZOCAINE;TRANSPORT
日期:	1998-09-01
上傳時間:	2010-03-09 09:57:55 (UTC+8)
出版者:	中國化學工程學會
摘要:	In the present work, the effect of medium on the drug permeation rate through polymeric membranes was investigated, The medium used in this work was ethanol-water solution of which the property can be adjusted by varying the ethanol composition. The membrane used was the polyurethane membrane and the model drug was nitroglycerin. The results indicate that an increase in the ethanol concentration in medium can have two effects: it can increase the nitroglycerin solubility in the donor and thus decrease the partition coefficient, and it can increase the degree of swelling of the polyurethane membrane and thus result in higher nitroglycerin diffusivity. When the ethanol concentration is lower than 65 wt%, the effect of partition dominates and increasing ethanol concentration results in decreasing nitroglycerin permeability. On the other hand, when the ethanol concentration is higher than 65 wt%, the effect of swelling on diffusivity dominates and increasing ethanol concentration results in increasing nitroglycerin permeability. Due to the competition between these two effects, a minimum nitroglycerin permeability occurs when the ethanol concentration is around 65 wt%.
關聯:	中國化學工程學會會誌=Journal of the Chinese Institute of Chemical Engineers 29(5), pp.337-343
顯示於類別:	[化學工程與材料工程學系暨研究所] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
	0Kb	Unknown	301	檢視/開啟

在機構典藏中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....