Effect of Medium on the Permeation of Drugs Through Polymeric Membranes: Competition between Swelling and Partition

淡江大學機構典藏 > 工學院 > 化學工程與材料工程學系暨研究所 > 期刊論文 > Item 987654321/44151

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题名:	Effect of Medium on the Permeation of Drugs Through Polymeric Membranes: Competition between Swelling and Partition
其它题名:	溶媒對藥物透過高分子膜之影響: 膨潤效應與分配效應之競爭
作者:	王大銘;葉秀敏;賴君義
贡献者:	淡江大學化學工程與材料工程學系
关键词:	SWOLLEN MEMBRANES;SOLUTE DIFFUSION;BENZOCAINE;TRANSPORT
日期:	1998-09-01
上传时间:	2010-03-09 09:57:55 (UTC+8)
出版者:	中國化學工程學會
摘要:	In the present work, the effect of medium on the drug permeation rate through polymeric membranes was investigated, The medium used in this work was ethanol-water solution of which the property can be adjusted by varying the ethanol composition. The membrane used was the polyurethane membrane and the model drug was nitroglycerin. The results indicate that an increase in the ethanol concentration in medium can have two effects: it can increase the nitroglycerin solubility in the donor and thus decrease the partition coefficient, and it can increase the degree of swelling of the polyurethane membrane and thus result in higher nitroglycerin diffusivity. When the ethanol concentration is lower than 65 wt%, the effect of partition dominates and increasing ethanol concentration results in decreasing nitroglycerin permeability. On the other hand, when the ethanol concentration is higher than 65 wt%, the effect of swelling on diffusivity dominates and increasing ethanol concentration results in increasing nitroglycerin permeability. Due to the competition between these two effects, a minimum nitroglycerin permeability occurs when the ethanol concentration is around 65 wt%.
關聯:	中國化學工程學會會誌=Journal of the Chinese Institute of Chemical Engineers 29(5), pp.337-343
显示于类别:	[化學工程與材料工程學系暨研究所] 期刊論文

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