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    題名: A novel zebrafish mutant with wavy-notochord: An effective biological index for monitoring the copper pollution of water from natural resources
    作者: Chen, Yau-hung;Lin, Ji-sheng
    貢獻者: 淡江大學生命科學研究所
    關鍵詞: bone;copper;notochord;toxicity;zebrafish
    日期: 2011-02
    上傳時間: 2010-02-23 14:03:41 (UTC+8)
    出版者: Hoboken: John Wiley & Sons, Inc.
    摘要: We identified a novel zebrafish mutant that has wavy-notochord phenotypes, such as severely twisted notochord and posterior malformations, but has normal melanocytes. Histological evidences showed that proliferating vacuolar cells extended their growth to the muscle region, and consequently caused the wavy-notochord phenotypes. Interestingly, those malformations can be greatly reversed by exposure with copper, suggesting that copper plays an important role on wavy-notochord phenotypes. In addition, after long-term copper exposure, the surviving larvae derived from wavy-notochord mutants displayed bone malformations, such as twisted axial skeleton and osteophyte. These phenotypic changes and molecular evidences of wavy-notochord mutants are highly similar to those embryos whose lysyl oxidases activities have been inactivated. Taken together, we propose that (i) the putative mutated genes of this wavy-notochord mutant might be highly associated with the lysyl oxidase genes in zebrafish; and (ii) this fish model is an effective tool for monitoring copper pollution of water from natural resources.
    關聯: Environmental Toxicology 26(1), pp.103-109
    DOI: 10.1002/tox.20534
    顯示於類別:[生命科學研究所] 期刊論文


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