English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 63187/95884 (66%)
造访人次 : 4570789      在线人数 : 164
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻

    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/42013

    题名: A novel zebrafish mutant with wavy-notochord: An effective biological index for monitoring the copper pollution of water from natural resources
    作者: Chen, Yau-hung;Lin, Ji-sheng
    贡献者: 淡江大學生命科學研究所
    关键词: bone;copper;notochord;toxicity;zebrafish
    日期: 2011-02
    上传时间: 2010-02-23 14:03:41 (UTC+8)
    出版者: Hoboken: John Wiley & Sons, Inc.
    摘要: We identified a novel zebrafish mutant that has wavy-notochord phenotypes, such as severely twisted notochord and posterior malformations, but has normal melanocytes. Histological evidences showed that proliferating vacuolar cells extended their growth to the muscle region, and consequently caused the wavy-notochord phenotypes. Interestingly, those malformations can be greatly reversed by exposure with copper, suggesting that copper plays an important role on wavy-notochord phenotypes. In addition, after long-term copper exposure, the surviving larvae derived from wavy-notochord mutants displayed bone malformations, such as twisted axial skeleton and osteophyte. These phenotypic changes and molecular evidences of wavy-notochord mutants are highly similar to those embryos whose lysyl oxidases activities have been inactivated. Taken together, we propose that (i) the putative mutated genes of this wavy-notochord mutant might be highly associated with the lysyl oxidase genes in zebrafish; and (ii) this fish model is an effective tool for monitoring copper pollution of water from natural resources.
    關聯: Environmental Toxicology 26(1), pp.103-109
    DOI: 10.1002/tox.20534
    显示于类别:[生命科學研究所] 期刊論文


    档案 描述 大小格式浏览次数
    1520-4081_26(1)p103-109.pdf5632KbAdobe PDF560检视/开启



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈