Functional Dihydro-1H-imidazole Derivatives for MALDI Signal Enhancement of a Lysine-Specific Chemical Modification

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/42006

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题名:	Functional Dihydro-1H-imidazole Derivatives for MALDI Signal Enhancement of a Lysine-Specific Chemical Modification
作者:	Ho, Ming-yi;Shieh, Yu-tse;Liao, Chung-lin;Chen, Yau-hung;Cheng, Chien-chung
贡献者:	淡江大學生命科學研究所
关键词:	MALDI;Dihydroimidazole;Lysine-specific;Guanidinium;Signal enhancement;Mass spectrometry
日期:	2009
上传时间:	2010-02-23 13:59:09 (UTC+8)
出版者:	臺北市：中國化學學會
摘要:	The preparation of 2-methoxy-4,5-dihydro-1H-imidazole (MeO-DHIM) was accomplished by one-step synthesis of O-methyl-isourea. The signal enhancement induced by these attached moieties increases in an order of compound 1 ≈ 4 < 2 < 5 ≈ 6 < 3 in MALDI mass spectrometry. Peptide-compound 3 adduct was approximately 20 times signal enhancement of the unmodified peptide.
關聯:	Journal of the Chinese Chemical Society 56(5), pp.987-994
DOI:	10.1002/jccs.200900144
显示于类别:	[化學學系暨研究所] 期刊論文

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