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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/42006


    Title: Functional Dihydro-1H-imidazole Derivatives for MALDI Signal Enhancement of a Lysine-Specific Chemical Modification
    Authors: Ho, Ming-yi;Shieh, Yu-tse;Liao, Chung-lin;Chen, Yau-hung;Cheng, Chien-chung
    Contributors: 淡江大學生命科學研究所
    Keywords: MALDI;Dihydroimidazole;Lysine-specific;Guanidinium;Signal enhancement;Mass spectrometry
    Date: 2009
    Issue Date: 2010-02-23 13:59:09 (UTC+8)
    Publisher: 臺北市:中國化學學會
    Abstract: The preparation of 2-methoxy-4,5-dihydro-1H-imidazole (MeO-DHIM) was accomplished by one-step synthesis of O-methyl-isourea. The signal enhancement induced by these attached moieties increases in an order of compound 1 ≈ 4 < 2 < 5 ≈ 6 < 3 in MALDI mass spectrometry. Peptide-compound 3 adduct was approximately 20 times signal enhancement of the unmodified peptide.
    Relation: Journal of the Chinese Chemical Society 56(5), pp.987-994
    DOI: 10.1002/jccs.200900144
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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