Effect of cell membrane structure of human erythrocyte on its electrophoresis

淡江大學機構典藏 > 理學院 > 應用數學與數據科學學系 > 期刊論文 > Item 987654321/41688

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题名:	Effect of cell membrane structure of human erythrocyte on its electrophoresis
作者:	Hsu, Jyh-ping;Lin, Sung-hwa;曾琇瑱;Tseng, Shio-jenn
贡献者:	淡江大學數學學系
关键词:	Cell membrane structure;Human erythrocyte;Electrophoresis;Mathematical model
日期:	2003-11-01
上传时间:	2010-01-28
出版者:	Elsevier
摘要:	The electrophoretic behavior of human erythrocyte is investigated theoretically. The present analysis extends previous studies to that the effect of the membrane structure of a cell is taken into account. The result obtained provides a useful tool for the estimation of the surface properties of human erythrocyte through electrophoretic measurements. Fitting the present model to the experimental data of Haydon and Seaman [Arch. Biochem. Biophys. 122 (1967) 126], for example, reveals that the surface charge of erythrocyte arises mainly from the dissociation of three functional groups, which bond to different sites on cell membrane : (a) N-acetylneuraminic acid (sialic acid) with pKHANaa=2.6, (b) some kind of α-carboxylic acid with pKHAα−ca=3.35, (c) weak amino base functional group with pKBH+=8.5. The distribution of Na+ in the protein layer of a cell is found to vary with the pH of the bulk liquid phase, the possible implication of this phenomenon to cell physiology is discussed.
關聯:	Colloids and Surfaces B: Biointerfaces 32(3), pp.203-212
DOI:	10.1016/S0927-7765(03)00158-9
显示于类别:	[應用數學與數據科學學系] 期刊論文

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