Modeling the controlled release of drug embedded in a plate-like polymer matrix

淡江大學機構典藏 > 理學院 > 數學學系暨研究所 > 期刊論文 > Item 987654321/41671

請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/41671

題名:	Modeling the controlled release of drug embedded in a plate-like polymer matrix
作者:	Lin, Sung-hwa;Hsu, Jyh-ping;曾琇瑱;Tseng, Shio-jenn
貢獻者:	淡江大學數學學系
關鍵詞:	Desorption;Higuchi model;Interface;Mathematical modelling;Polymer;Moving boundary problem
日期:	2005-03-01
上傳時間:	2010-01-28
出版者:	Elsevier
摘要:	The controlled release of over-loaded drug in a plate-like polymer matrix, the Higuchi's problem, is investigated theoretically. Taking the advantage of Landau transformation, we restore the concentration profile of drug in a polymer matrix, the rate of release of drug from the polymer matrix, and the temporal variation of location of the moving boundary taking the external mass transfer resistance into account. The applicability of the series of moving boundaries, a numerical approach often adopted, is examined. We found that it may become ineffective when the over-loading of drug in a polymer matrix is too small. In contrast, our method has no such limitation. We conclude that assuming the transfer of drug to occur at a pseudo-steady-state condition is inadequate if the degree of over-loading for drug is low or the external mass transfer resistance is significant.
關聯:	Chemical Engineering Science 60(5), pp.1295-1301
DOI:	10.1016/j.ces.2004.10.003
顯示於類別:	[數學學系暨研究所] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	158	檢視/開啟
Modeling the controlled release of drug embedded in a plate-like polymer matrix.pdf		232Kb	Adobe PDF	1	檢視/開啟

在機構典藏中所有的資料項目都受到原著作權保護.

TAIR相關文章