淡江大學機構典藏:Item 987654321/41656
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 62830/95882 (66%)
造訪人次 : 4047812      線上人數 : 584
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/41656


    題名: Expression of nuclear retinoid receptors in normal, premalignant and malignant gastric tissues determined by in situ hybridization
    作者: Jiang, Shun-yuan;Shen, Shyue-ren;Shyu, Rong-yaun;Yu, Jrh-cheng;Harn, Horng-jyh;Yeh, Ming-yang;Lee, May Mei-shyuan;張玉坤;Chang, Yue-cune
    貢獻者: 淡江大學數學學系
    關鍵詞: gastric cancer;retinoic acid receptor;retinoid x receptor;in situ hybridization;mRNA
    日期: 1999-03-28
    上傳時間: 2010-01-28
    出版者: Nature Publishing Group
    摘要: Retinoids exhibit multiple functions through interaction with nuclear retinoid receptors and have growth-suppressive activity on gastric cancer cells. To better understand the roles of nuclear retinoid receptors during gastric carcinogenesis, we have used in situ hybridization to investigate expression of retinoic acid receptors (RARs) and retinoid x receptors (RXRs) in premalignant and malignant formalin-fixed paraffin-embedded gastric tissues. Histological sections of eight normal, 17 distal normal and nine gastric cancer tissues were hybridized with non-radioactive RNA probes for subtypes of RAR and RXR. Expression of RARα, RARβ, RARγ, RXRα and RXRβ was found in most cell types in gastric mucosa tissues from normal individuals as well as in distal normal tissues from cancer patients. Expression of RARα and RARβ were found in three and seven cancer tissues, respectively, and levels of RXRα mRNA were significantly decreased in poorly differentiated cancer tissues. Among the five investigated nuclear retinoid receptors, only expression of RARα mRNA was significantly decreased in intestinal metaplasia, dysplasia and cancer tissues when compared to adjacent normal tissues. In conclusion, normal gastric mucosa expressed both RARs and RXRs, which supports the physiological role of retinoic acid on normal gastric mucosa. The decrease in RARα expression in premalignant and malignant gastric tissues suggests a significant role of RARα during gastric carcinogenesis.
    關聯: British Journal of Cancer 80(1), pp.206-214
    DOI: 10.1038/sj.bjc.6690340
    顯示於類別:[數學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    Expression of nuclear retinoid receptors in normal, premalignant and malignant gastric tissues determined by in situ hybridization.pdf7366KbAdobe PDF1檢視/開啟
    index.html0KbHTML188檢視/開啟
    index.html0KbHTML179檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋