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    题名: Expression of nuclear retinoid receptors in normal, premalignant and malignant gastric tissues determined by in situ hybridization
    作者: Jiang, Shun-yuan;Shen, Shyue-ren;Shyu, Rong-yaun;Yu, Jrh-cheng;Harn, Horng-jyh;Yeh, Ming-yang;Lee, May Mei-shyuan;張玉坤;Chang, Yue-cune
    贡献者: 淡江大學數學學系
    关键词: gastric cancer;retinoic acid receptor;retinoid x receptor;in situ hybridization;mRNA
    日期: 1999-03-28
    上传时间: 2010-01-28
    出版者: Nature Publishing Group
    摘要: Retinoids exhibit multiple functions through interaction with nuclear retinoid receptors and have growth-suppressive activity on gastric cancer cells. To better understand the roles of nuclear retinoid receptors during gastric carcinogenesis, we have used in situ hybridization to investigate expression of retinoic acid receptors (RARs) and retinoid x receptors (RXRs) in premalignant and malignant formalin-fixed paraffin-embedded gastric tissues. Histological sections of eight normal, 17 distal normal and nine gastric cancer tissues were hybridized with non-radioactive RNA probes for subtypes of RAR and RXR. Expression of RARα, RARβ, RARγ, RXRα and RXRβ was found in most cell types in gastric mucosa tissues from normal individuals as well as in distal normal tissues from cancer patients. Expression of RARα and RARβ were found in three and seven cancer tissues, respectively, and levels of RXRα mRNA were significantly decreased in poorly differentiated cancer tissues. Among the five investigated nuclear retinoid receptors, only expression of RARα mRNA was significantly decreased in intestinal metaplasia, dysplasia and cancer tissues when compared to adjacent normal tissues. In conclusion, normal gastric mucosa expressed both RARs and RXRs, which supports the physiological role of retinoic acid on normal gastric mucosa. The decrease in RARα expression in premalignant and malignant gastric tissues suggests a significant role of RARα during gastric carcinogenesis.
    關聯: British Journal of Cancer 80(1), pp.206-214
    DOI: 10.1038/sj.bjc.6690340
    显示于类别:[數學學系暨研究所] 期刊論文

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