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| 題名: | Glycine transporter-1 inhibitor, N-methyglycine (sarcosine), added to clozapine for the treatment of schizophrenia |
| 作者: | Lane, Hsien-yuan;Huang, Chieh-liang;Wu, Po-lun;Liu, Yi-ching;張玉坤;Chang, Yue-cune;張玉坤;Lin, Pao-yen;Chen, Po-wei;Tsai, Guochuan |
| 貢獻者: | 淡江大學數學學系 |
| 關鍵詞: | Glutamate;GlyT-1;N-methyl-D-aspartate;sarcosine;schizophrenia;treatment |
| 日期: | 2006-09-15 |
| 上傳時間: | 2010-01-28 |
| 出版者: | Elsevier |
| 摘要: | Background
Agonists at the N-methyl-D-aspartate (NMDA)-glycine site (D-serine, glycine, D-alanine and D-cycloserine) and glycine transporter-1 (GlyT-1) inhibitor (N-methylglycine, or called sarcosine) both improve the symptoms of stable chronic schizophrenia patients receiving concurrent antipsychotics. Previous studies, however, found no advantage of D-serine, glycine, or D-cycloserine added to clozapine. The present study aims to determine the effects of sarcosine adjuvant therapy for schizophrenic patients receiving clozapine treatment.
Methods
Twenty schizophrenic inpatients enrolled in a 6-week double-blind, placebo-controlled trial of sarcosine (2 g/day) which was added to their stable doses of clozapine. Measures of clinical efficacy and side-effects were determined every other week.
Results
Sarcosine produced no greater improvement when co-administered with clozapine than placebo plus clozapine at weeks 2, 4, and 6. Sarcosine was well tolerated and no significant side-effect was noted.
Conclusions
Unlike patients treated with other antipsychotics, patients who received clozapine treatment exhibit no improvement by adding sarcosine or agonists at the NMDA-glycine site. Clozapine possesses particular efficacy, possibly related to potentiation of NMDA-mediated neurotransmission. This may contribute to the clozapine’s unique clinical efficacy and refractoriness to the addition of NMDA-enhancing agents. |
| 關聯: | Biological Psychiatry 60(6), pp.645-649 |
| DOI: | 10.1016/j.biopsych.2006.04.005 |
| 顯示於類別: | [應用數學與數據科學學系] 期刊論文
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