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    题名: D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia
    作者: Tsai, Guochuan E.;Yang, Pinchen;張玉坤;Chang, Yue-cune;Chong, Mian-yoon
    贡献者: 淡江大學數學學系
    关键词: N-methyl-D-aspartate;glutamate;schizophrenia;treatment-resistant
    日期: 2006-02-01
    上传时间: 2010-01-28
    出版者: Elsevier
    摘要: Background

    Hypofunction of the N-methyl-d-aspartate (NMDA) subtype glutamate receptor had been implicated in the pathophysiology of schizophrenia. Treatment with D-serine, glycine, endogenous full agonists of the glycine site of the NMDA receptor (NMDA-glycine site), D-cycloserine, a partial agonist, or sarcosine, a glycine transporter-1 inhibitor, improves the symptoms of schizophrenia. D-alanine is another endogenous agonist of the NMDA-glycine site that might have beneficial effects on schizophrenia.

    Methods

    Thirty-two schizophrenic patients enrolled in a 6-week double-blind, placebo-controlled trial of D-alanine (100 mg/kg/day), which was added to their stable antipsychotic regimens. Measures of clinical efficacy and side effects were determined every other week.

    Results

    Patint who received D-alanine treatment revealed significant reductions in their Clinical Global Impression Scale and Positive and Negative Syndrome Scale (PANSS) total scores. The Scale for the Assessment of Negative Symptoms and PANSS subscores of positive and cognitive symptoms were improved. D-alanine was well tolerated, and no significant side effect was noted.

    Conclusions

    The significant improvement with the D-alanine further supports the hypothesis of hypofunction of NMDA neurotransmission in schizophrenia and strengthens the proof of the principle that NMDA-enhancing treatment is a promising approach for the pharmacotherapy of schizophrenia.
    關聯: Biological Psychiatry 59(3), pp.230-234
    DOI: 10.1016/j.biopsych.2005.06.032
    显示于类别:[數學學系暨研究所] 期刊論文

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