Treatment of centrally located hepatocellular carcinoma by central hepatectomy

doi:10.1067/msy.2003.102

機構典藏 > College of Sciences > Graduate Institute & Department of Mathematics > Journal Article > Item 987654321/41467

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Title:	Treatment of centrally located hepatocellular carcinoma by central hepatectomy
Authors:	Hu, Rey-heng;Lee, Po-huang;張玉坤;Chang, Yue-cune;Ho, Ming-chih;Yu, Sen-chang
Contributors:	淡江大學數學學系
Date:	2003-03-01
Issue Date:	2010-01-28 07:38:08 (UTC+8)
Publisher:	Elsevier
Abstract:	Background. For treatment of centrally located hepatocellular carcinoma (HCC), central hepatectomy (including central trisegmentectomy [Couinaud's segments 4, 5, and 8] and anterior segmentectomy [Couinaud's segments 5 and 8]) may have an important advantage (ie, preservation of nontumorous parenchyma) over conventional lobectomy or extended lobectomy. For determination of the efficacy of this technique, we compared the outcomes of patients with HCC who underwent treatment with the central and conventional methods. Patients and Methods. In our institute, 52 patients with HCC underwent treatment with central hepatectomy (group 1) and 63 patients with comparable tumor size underwent treatment with conventional major hepatectomy (group 2) from November 1993 to April 1999. Overall patient survival and disease-free survival rates were calculated and analyzed. The possible prognostic risk factors for patient and disease-free survival in group 1 were analyzed. Results. Group 1 had comparable overall patient and disease-free survival rates with those of group 2. Vascular invasion, higher pathology grading, and resection margin less than 1 cm appeared to be the prognostic factors for overall patient survival, and vascular invasion was the only risk factor for disease-free survival. Conclusion. Central hepatectomy is a safe and effective operative procedure for the treatment of centrally located HCC. The patient and disease-free survival rates were the same as those of conventional major hepatectomy. Although it is technically more demanding, central hepatectomy preserves more nontumor liver parenchyma, which is important for the survival of those patients with liver cirrhosis.
Relation:	Surgery 133(3), pp.251-256
DOI:	10.1067/msy.2003.102
Appears in Collections:	[Graduate Institute & Department of Mathematics] Journal Article

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