English  |  正體中文  |  简体中文  |  Items with full text/Total items : 55241/89544 (62%)
Visitors : 10729936      Online Users : 21
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/41464


    Title: A statistical assessment on the stochastic relationship between biomarker concentrations and environmental exposures
    Authors: 陳主智;Chen, Chu-chih;Wu, Kuen-yuh;Chang, Ming J. W.
    Contributors: 淡江大學數學學系
    Keywords: Biological exposure indices;Inter-individual difference;Random-effects model;Physiologically-based pharmacokinetic model;Sampling design Threshold limit value
    Date: 2004-12-01
    Issue Date: 2010-01-28 07:37:56 (UTC+8)
    Publisher: Springer
    Abstract: Biological monitoring has gradually developed into a powerful tool in the identification and quantification of exposures to occupational and/or environmental hazards in environmental and occupational health studies. Aggregate individual exposure to pollutants and evidence for exploring dose-response relationship in the human bodies can be assessed through biomarker measurements. The existence of inter-individual differences among a study population, however, often hampers the relationship assessment between exposure and the biomarker. In this paper, a statistical random effects model identified from a simplified one-compartment pharmacokinetic model is applied to establish the dynamic relationship between a biomarker and its corresponding external exposure. This model avoids the complex parameter estimation problem encountered using a physiologically based pharmacokinetic (PBPK) model, and incorporates inter-individual variations often ignored in the usual regression approach. In addition, the relevant parameters for the generic kinetic process can be estimated directly. As a guideline for preliminary sampling strategy, tables of required sample sizes and the number of repeated measurements to achieve the desired statistical power and test efficiency are given. The currently established biological exposure indices (BEIs) for benzene and methyl chloroform are employed to illustrate the impact of inter- individual variations on the percentages of protection for workers exposed to the threshold limit value (TLV) of the corresponding chemical.
    Relation: Stochastic Environmental Research and Risk Assessment 18(6), pp.377-385
    DOI: 10.1007/s00477-004-0208-2
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

    Files in This Item:

    File Description SizeFormat
    A statistical assessment on the stochastic relationship between biomarker concentrations and environmental exposures.pdf273KbAdobe PDF0View/Open
    index.html0KbHTML89View/Open
    index.html0KbHTML43View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback