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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/41460

    Title: Two-sample scale tests for comparison of metabolic rates for styrene in previously exposed and unexposed groups
    Authors: 陳主智;Chen, Chu-chih
    Contributors: 淡江大學數學學系
    Keywords: Hodges–Lehmann estimator;mixed-eects model;permutation test;physiologicallybased pharmacokinetic model;Wilcoxon rank-sum test
    Date: 2004-02-01
    Issue Date: 2010-01-28 07:37:25 (UTC+8)
    Publisher: Wiley-Blackwell
    Abstract: Statistical analysis procedure in two-sample treatment difference, as well as alternative hypothesis, may play a central role in statistical inference, especially in small sample size case. In this paper, simple non-parametric two-sample permutation tests for scale difference based on the Hodges–Lehmann estimator are reformulated, and are applied to a study examining whether previous styrene exposure increases (thus a one-sided alternative hypothesis rather than a two-sided one) the human liver's metabolic ability to convert styrene into styrene oxide, in which a three-compartment physiologically based pharmacokinetic (PBPK) model was used to compare the estimated metabolic constant κamong the previously exposed and unexposed groups. Contrary to the previous conclusion, the proposed tests for scale difference identified from a mixed-effects model showed a significant result.
    Relation: Statistics in Medicine 23(4), pp.591-599
    DOI: 10.1002/sim.1617
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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