English  |  正體中文  |  简体中文  |  Items with full text/Total items : 55222/89520 (62%)
Visitors : 10722235      Online Users : 21
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/41438

    Title: Dose-dependent reduced haloperidol/haloperidol ratios: influence of patient-related variables
    Other Titles: 劑量相關之降低RH/HL比例:病人相關因素之影響
    Authors: Lane, Hsien-yuan;Chang, Wen-ho;張玉坤;Chang, Yue-cune;Hu, Oliver Yao-pu;Lin, Hsin-nan;Jann, Michael W.;Hu, Wei-herng
    Contributors: 淡江大學數學學系
    Keywords: Dosage;Plasma levels;Age;Chinese
    Date: 1997-09-19
    Issue Date: 2010-01-28 07:34:13 (UTC+8)
    Publisher: Elsevier
    Abstract: lasma reduced haloperidol (RH) concentrations or RH to haloperidol (HL) ratios have been suggested to be important in determining the clinical efficacy and extrapyramidal side effects of HL. In this study, we measured the steady-state plasma HL and RH levels by high performance liquid chromatography and analyzed the effects of various variables (dose, gender, age, and body weight) on RH/HL ratios in four dose groups of Chinese schizophrenic inpatients: 10 mg/day (n=84), 20 (n=111), 30 (n=29), and 60 (n=55). In addition, the polymorphic distribution of RH/HL ratios, suggested by previous investigators, was further tested in each dosage group (for controlling the potential dosage effect on RH/HL ratios). As a result, both age and body weight could influence RH/HL ratios. Each year increase in age (after adjusting the effects of gender, body weight, and dosage) would elevate the RH/HL ratio by 0.0067 (P<0.0001). On the other hand, after adjusting gender, age, and dosage effects, each kg increment in body weight would decrease the RH/HL ratio by 0.0044 (P<0.01). Gender did not influence the ratio. Furthermore, the high dosage groups had higher RH/HL ratios (even with other variables being controlled). In comparison with the 10 mg group, the 60 mg group exhibited a higher mean RH/HL ratio by 0.84 (P<0.0001) and the 30 mg group did by 0.31 (P<0.0001). The 20 mg group was almost equal to the 10 mg group in RH/HL ratios. Besides, at each dosage group, the frequency distribution of RH/HL ratios seemed to be predominantly unimodal with a small proportion of extreme outliers. The results of this study clearly indicate that aging or a high dose (≥30 mg/day) of HL could raise the plasma RH/HL ratio, while an increasing body weight would reduce that. In contrast, gender does not affect the ratios. © 1997 Elsevier Science Ireland Ltd.
    Relation: Psychiatry Research 72(2), pp.127-132
    DOI: 10.1016/S0165-1781(97)00078-4
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

    Files in This Item:

    File Description SizeFormat

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback