Modeling the repair of radiation-induced DNA double-strand breaks

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Title:	Modeling the repair of radiation-induced DNA double-strand breaks
Other Titles:	輻射線引發之DN 雙股斷裂修復行為的動態模擬
Authors:	Tseng, Shio-jenn;曾琇瑱;Hsu, Jyh-ping;徐治平
Contributors:	淡江大學數學學系
Date:	1991-02
Issue Date:	2010-01-28 07:34:09 (UTC+8)
Publisher:	行政院國家科學委員會
Abstract:	A problem often overlooked in the study of the repair of radiation-induced DNA double-strand breads (DSBs) is the question of what the status of a regular site is in the DNA duplex immediately after a radiation treatment. Here, we suggest a mixed repair mechanism which consists of a gradual process and an instantaneous process. A comparison of the present kinetic model with those which have appeared in the literature shows that the former is a generalization of the latter. We have shown that different repair mechanisms may lead to equivalent mathematical representations. Therefore, care must be taken in interpreting the repair mechanism on the basis of the experimentally observed transient number of DSBs.
Relation:	Proceedings of the National Science Council, Republic of China. Part B: Life Sciences 15(1), pp.28-31
Appears in Collections:	[Graduate Institute & Department of Mathematics] Journal Article

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