A stochastic analysis of the repair of radiation-induced DNA double-strand breaks

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Title:	A stochastic analysis of the repair of radiation-induced DNA double-strand breaks
Authors:	曾琇瑱;Tseng, Shio-jenn;Hus, Jyh-ping
Contributors:	淡江大學數學學系
Date:	1990-06
Issue Date:	2010-01-28 07:31:14 (UTC+8)
Publisher:	Elsevier
Abstract:	A three-state stochastic model is described for the repair of radiation-induced double-strand breaks (DSBs) in DNA. If irradiated, a site or region in DNA is assumed to be in a potentially damaged state; this site may either become permanently damaged or be repaired after a certain period of time. The result of the analysis of the available experimental data reveals that the present two-parameter model is capable of interpreting the rapid decrease in the number of DSBs in the initial period, which cannot be predicted by previously proposed models. The stochastic analysis yields not only the temporal variation of the mean of the number of DSBs but also its variance, and therefore is a generalization of the conventional deterministic models.
Relation:	Mathematical Biosciences 100(1), pp.21-31
DOI:	10.1016/0025-5564(90)90045-Z
Appears in Collections:	[Graduate Institute & Department of Mathematics] Journal Article

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