Shifting from haloperidol to risperidone for behavioral disturbances in dementia : safety, response predictors, and mood effects

doi:10.1097/00004714-200202000-00002

淡江大學機構典藏 > 理學院 > 數學學系暨研究所 > 期刊論文 > Item 987654321/41276

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/41276

题名:	Shifting from haloperidol to risperidone for behavioral disturbances in dementia : safety, response predictors, and mood effects
作者:	Lane, Hsien-yuan;張玉坤;Chang, Yue-cune;Su, Muh-hwan;Chiu, Chi-chiang;Huang, Ming-chyi;Chang, Wen-ho
贡献者:	淡江大學數學學系
日期:	2002-02
上传时间:	2010-01-28 07:09:59 (UTC+8)
出版者:	Lippincott, Williams & Wilkins
摘要:	For agitated dementia showing insufficient response to conventional antipsychotics, the feasibility of transition to atypical agents remains unknown. Sixty-two Chinese inpatients with dementia and disruptive behaviors were recruited into an 8-week screening trial of haloperidol. Thirty-five (56%) of them responded insufficiently. They then entered a prospective, 16-week, open-labeled study. Haloperidol was abruptly shifted to risperidone 0.5 mg/day at weeks 1 to 4 and then 1 mg/day at weeks 5 to 12. At weeks 13 to 16, the regimen was shifted back to haloperidol at previous doses, mostly 1 mg/day. Safety, efficacy, cognition, and moods were evaluated at least every 4 weeks. Generalized estimating equation methods were used for determining the effects of the prognostic variables on the outcome values. Risperidone, particularly at 0.5 mg/day, was generally tolerable. The Brief Psychiatric Rating Scale (BPRS) score decreased progressively under risperidone treatment; at week 12, 16 (46%) patients showed response (≥25% reduction in the BPRS). Patients with vascular dementia were more likely to respond than those with Alzheimer’s disease (p = 0.02). Haloperidol reinstitution resulted in no further improvement, except trend increments in motor symptoms. Risperidone also tended to benefit the performance on the Behavioral Pathology in Alzheimer’s Disease Rating Scale. Six (17%) patients improved on moods and self-care with risperidone. These preliminary results suggest that crossover from haloperidol to risperidone is generally safe and effective and may produce favorable moods in agitated dementia patients. Vascular dementia is a predictor of treatment response. In contrast to the dose (1 mg/day) recommended for most white individuals, 0.5 mg/day could be tried at first in Chinese patients. Because of the design’s limitations, further controlled studies are warranted.
關聯:	Journal of Clinical Psychopharmacology 22(1), pp.4-10
DOI:	10.1097/00004714-200202000-00002
显示于类别:	[數學學系暨研究所] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
index.html	0Kb	HTML	112	检视/开启

在機構典藏中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....