English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 60934/93528 (65%)
造訪人次 : 1562096      線上人數 : 9
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/41276

    題名: Shifting from haloperidol to risperidone for behavioral disturbances in dementia : safety, response predictors, and mood effects
    作者: Lane, Hsien-yuan;張玉坤;Chang, Yue-cune;Su, Muh-hwan;Chiu, Chi-chiang;Huang, Ming-chyi;Chang, Wen-ho
    貢獻者: 淡江大學數學學系
    日期: 2002-02
    上傳時間: 2010-01-28 07:09:59 (UTC+8)
    出版者: Lippincott, Williams & Wilkins
    摘要: For agitated dementia showing insufficient response to conventional antipsychotics, the feasibility of transition to atypical agents remains unknown. Sixty-two Chinese inpatients with dementia and disruptive behaviors were recruited into an 8-week screening trial of haloperidol. Thirty-five (56%) of them responded insufficiently. They then entered a prospective, 16-week, open-labeled study. Haloperidol was abruptly shifted to risperidone 0.5 mg/day at weeks 1 to 4 and then 1 mg/day at weeks 5 to 12. At weeks 13 to 16, the regimen was shifted back to haloperidol at previous doses, mostly 1 mg/day. Safety, efficacy, cognition, and moods were evaluated at least every 4 weeks. Generalized estimating equation methods were used for determining the effects of the prognostic variables on the outcome values. Risperidone, particularly at 0.5 mg/day, was generally tolerable. The Brief Psychiatric Rating Scale (BPRS) score decreased progressively under risperidone treatment; at week 12, 16 (46%) patients showed response (≥25% reduction in the BPRS). Patients with vascular dementia were more likely to respond than those with Alzheimer’s disease (p = 0.02). Haloperidol reinstitution resulted in no further improvement, except trend increments in motor symptoms. Risperidone also tended to benefit the performance on the Behavioral Pathology in Alzheimer’s Disease Rating Scale. Six (17%) patients improved on moods and self-care with risperidone. These preliminary results suggest that crossover from haloperidol to risperidone is generally safe and effective and may produce favorable moods in agitated dementia patients. Vascular dementia is a predictor of treatment response. In contrast to the dose (1 mg/day) recommended for most white individuals, 0.5 mg/day could be tried at first in Chinese patients. Because of the design’s limitations, further controlled studies are warranted.
    關聯: Journal of Clinical Psychopharmacology 22(1), pp.4-10
    DOI: 10.1097/00004714-200202000-00002
    顯示於類別:[數學學系暨研究所] 期刊論文


    檔案 大小格式瀏覽次數



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋