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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/41230

    Title: Electrophoresis of biological cells:charge-regulation and multivalent counterions association model
    Authors: Hsu, Jyh-ping;Hseih, Tien-Shiang;Young, Tai-Horng;曾琇瑱;Tseng, Shio-jenn
    Contributors: 淡江大學數學學系
    Date: 2003-04-01
    Issue Date: 2010-01-28 07:01:20 (UTC+8)
    Publisher: Wiley-Blackwell
    Abstract: The electrophoresis of a biological cell is analyzed theoretically. An entity, which is of amphoteric nature, is used to simulate its electrophoretic behavior. To reflect conditions of practical interest, we assume that the liquid phase contains mixed (a:b)+(c:b) electrolytes, where a and c are the valences of cations, and b is the valence of anions. We consider the case where the surface of a cell contains both bivalent acidic and monovalent basic functional groups, the dissociation/association of them yields fixed surface charge, and the multivalent cations in the liquid phase are allowed to combine with dissociated acidic functional groups, which has the effect of lowering the charge density on cell surface. The electrophoretic behaviors of a cell under various conditions are illustrated. The results obtained can be used to identify the types of functional groups that may be present on cell surface. On the other hand, if the surface functional groups involved in cell electrophoresis are known, then their density and the associated dissociation/association constants can be estimated from experimental data.
    Relation: Electrophoresis 24(9), pp.1338-1346
    DOI: 10.1002/elps.200390172
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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