本研究以六個不同結構範例探討結構最佳化設計問題，其結果顯示出所得到的結構外形比只使用傳統拓樸最佳化之結構外形更加的清晰，結構形狀更易於製造加工。期望以本研究之方法應用於工業界實際的結構設計問題上，能有效地達到結構最佳化的需求並增加製造上的便利性。 A Methodology of structural shape design by topology optimization and B-spline function was developed in this study. The finite element analysis software ANSYS was used for structural analysis. The optimum shape design was obtained by the concept of material distribution borrowed from density method with sequential linear programming. In addition to using the element growth-removal combined method (EGRCM) simultaneously to grow and remove the essential element and the non-essential element, the concept of B-spline curve was used to smooth the design shape.Three stages topology design was employed in this study. After three stages design strategy , the primitive optimum design can be improved to more practical design. Six examples were discussed in the numerical examples. The results of final design were better than the traditional topology design. We hope the results of this study can provide the convenience of manufacturing to the industry of structural design.