青光眼（glaucoma)是全球僅次於白內障導致視力喪失之主要病因。一般認為當眼球內眼壓（intraocular pressure）過高而超過眼球組織，尤其是視網膜神經所能承受之限度時，便造成神經視覺損壞和視野缺損進而導致失明。眼壓是由眼球內房水（aqueous humor）的生成與流出來平衡，當房水生成，流出平衡失調便會造成眼壓升高。根據醫學統計，95%正常人群之生理性眼壓範圍為10～21mmHg。造成房水調節功能障礙之原因非常複雜，而目前並無根治青光眼的方法，只能阻止眼壓不再升高而不能修復受損的視力。 本研究利用數值方法來分析眼球內壓力分布情形，以計算流體力學的觀點來探討房水流動對眼壓的影響，另外，本研究還探討隅角閉鎖型青光眼的壓力分布情形，討論當房水排出阻塞時其壓力變化，本研究使用工程分析軟體FLUENT 來做數值模擬和分析，並將分析和輸出結果提供給眼科學界做為參考。 Glaucoma, only second to Cataract, is the main cause of ablepsia in the world. Most of the people believe that optic nerve will be damage when the intraocular pressure exceeds the upper limit of eye tissue can take. This will cause meiosis and then ablepsia eventually. Intraocular pressure is balanced by accruing and discharging of aqueous humor. When the balance is fractured, the intraocular pressure will be increased. According to medical statistics, the range of physiology pressure of 95% of normal eyes is between 10 to 21mmHg. The reasons for aqueous humor unbalance are very complicate. There is no fundamental solution to cure Glaucoma for the time being. What Ophthalmologist can do now is to stop intraocular pressure from increasing, but not restoring damaged optic nerve for Glaucoma patient. In this research, numerical analysis model is built to analyze pressure distribution in an eye. CFD method is applied to investigate how aqueous humor affects the intraocular pressure. The pressure distribution of Close-angle Glaucoma is also examined, and the results will be provided as references in treating Glaucoma for Ophthalmologist
