青光眼，是一種致盲性眼睛疾病，更是僅次於白內障造成失明的主要病因。眼壓，由眼球內房水之生成率與流出率所決定，當房水之生成、流出平衡失調便造成眼壓升高。 隅角閉鎖型青光眼的造成是因為虹膜阻塞隅角，造成隅角閉鎖，而導致房水無法順利流出，眼壓因此逐漸升高。當眼球內眼壓長期過高，視網膜神經持續遭受壓迫，將造成視神經損壞，視野縮小。 本研究主要探討隅角閉鎖型青光眼眼球後房壓力的變化，模擬眼球後房受前房擠壓後的壓力分布趨勢，觀察當後房壓力產生變化時，對於視神經及其周圍細胞造成之影響。 Glaucoma, second only to cataract, is the major cause of losing eyesight in the world. Intraocular pressure is determined by the formation rate and shedding rate of aqueous humor. Intraocular pressure is raised through increased production or decreased outflow of aqueous humor. As the angle gets blocked by part of the iris, the fluid at the front of the eye cannot reach the angle and leave the eye. Therefore, the intraocular pressure increases gradually. It is generally acknowledged that excessive intraocular pressure, beyond the upper limit of optic nerve able to bear, makes the neural vision to be damaged, the visual field to be shrunk, flawed and damaged. The research in this thesis is conducted to study the pressure distributions in the posterior chamber of an eye for Angle-closure glaucoma. The numerical simulations are designed to find the pressure distribution in posterior chamber when the stress is transmitted from anterior chamber. The effects on optic nerve and cell around can be observed as the pressure distribution in posterior chamber changes.
