本研究擬製備紫外光敏感性幾丁聚醣(CS)，並以聚乙二醇二甲基丙烯酸酯(PEGDMA)作為交聯劑，在不添加額外的光起始劑下製備出幾丁聚醣交聯聚乙二醇二甲基丙烯酸酯薄膜。首先以甲基磺酸(CH3SO3H)溶解幾丁聚醣，由於一級胺基在甲基磺酸中會形成鹽類，因此同時可以達到保護胺基的作用，再加入肉桂醯氯(CIN)與幾丁聚醣上的氫氧基進行反應，即可得到具紫外光敏感性幾丁聚醣肉桂酯(CINCS)。藉由幾丁聚醣上之肉桂酯基(C6H5CH=CHCOO-)在紫外光下可進行光交聯的特性，將幾丁聚醣肉桂酯溶於甲酸溶液中，並加入聚乙二醇二甲基丙烯酸酯交聯劑，經過紫外光硬化處理後獲得幾丁聚醣交聯聚乙二醇二甲基丙烯酸酯薄膜(CS-g-PEG)。最後以元素分析(EA)、傅氏紅外線吸收光譜(FTIR)以及固態13C-NMR光譜進行材料結構分析，以及針對薄膜做熱性質分析(TGA、DSC及DMA)，拉伸測試，藥物滲透實驗等，進而評估幾丁聚醣交聯聚乙二醇二甲基丙烯酸酯薄膜的性質與其應用。由結構鑑定證實，在甲基磺酸系統下，可以有效的將胺基保留，並且成功使幾丁聚醣上的氫氧基與肉桂醯氯反應，得到具紫外光敏感性幾丁聚醣肉桂酯，且其確實有光起使的作用，可在不添加額外的光起始劑條件下與聚乙二醇二甲基丙烯酸酯，經過UV光聚合反應形成幾丁聚醣接枝聚乙二醇二甲基丙烯酸酯共聚物。 In this study, an UV-sensitive of chitosan was prepared by reaction with cinnamoyl chloride. The prepared UV-sensitive chitosan was then crosslinked with polyethylene glycol dimethyl acrylate(PEGDMA) without using any photo-initiator. Firstly, chitosan was dissolved in methanesulfonic acid followed by the addition of cinnamoyl chloride. The reaction was carried out in an ice-water bath to produce cinnamoyl chitosan. Secondly, cinnamoyl chitosan was dissolved in formic acid followed by the addition of PEGDMA. CS-g-PEG graft copolymers were obtained after UV-irradiation. EA and FTIR were used to analyze the chemical structures of graft copolymers. TGA and DMA were employed to measure the thermal properties of the prepared copolymers.
