芳香族肼化合物為合成一些吲哚(Indole)、吡唑(Pyrazole)、β-環內酯(β-Lactam)、喹口咢啉(Quinazoline)及其一些其他雜環化合物的前驅物,這些都是已知有生物活性的物質。而芳香族伸肼基化合物可轉換成芳香族肼與胺化合物,更進一步的可以繼續做衍生合成反應。本實驗室利用芳香族溴化合物、活化鎂(1,2-二溴乙烷當活化劑)與偶氮基化合物(DEAD)進行超音波化學誘導巴比艾爾型式反應生成芳香族伸肼基化合物。 另一個研究方向,許多抗腫瘤藥物、抑制劑、螢光物質和有機發光二極體(OLED)都可以找到以1,3-苯幷硫唑為中心的架構;其衍生物在藥性和工業化學上一直是研究上重要的課題之ㄧ。本實驗室發展利用天然脯胺酸(L-Proline)催化且在微波加熱的反應條件下,2-胺基苯硫吩與醛和酸類化合物進行縮合反應,生成1,3-苯幷硫唑化合物。 Aryl hydrazides are important precursors for synthesis of a variety of heterocycles such as indoles, pyrazoles, β-lactams, quinazolines and others, they are well known to be biologically active. In addition, aryl hydrazides can be transformed to aryl hydrazines and aryl amines, which can be further applied to synthesize heterocyclic compounds. Herein, our laboratory wish to report a novel synthetic method for preparation of aryl hydrazide from arylbromide, magnesium powder, 1,2-dibromoethane and diethyl azodicarboxylate via sonochemical Barbier-type reaction. In another part, the benzothiazole-based compounds which were the core structural moiety of antitumour agents, inhibitive agents and orangic light emitting diodes(OLED’s). Our laboratory developed a microwave-assisted method for synthesis of benzothiazoles from the direct condensation reaction of aryl- or alkyl- aldehyde or carboxylic acid with 2-aminothiophenol in the presence of L-proline as catalyst.