淡江大學機構典藏:Item 987654321/32797
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 64176/96941 (66%)
造访人次 : 9107285      在线人数 : 12436
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/32797


    题名: 兒茶酚加氧酶模型鐵錯合物之研究
    其它题名: Studies on the model catechol 1, 2-dioxygenase iron(III) complexes
    作者: 翁啟煌;Weng, Chi-huang
    贡献者: 淡江大學化學學系碩士班
    魏和祥;Wei, Ho-hsiang
    关键词: 內雙羥斷裂;兒茶酚1，2-雙加氧酚;鐵三價錯合物;X光結構;電子自旋光譜;Intradiol cleavage;Catechol 1,2-dioxygenase;Iron(III) complexes;X-ray structure;EPR spectrum
    日期: 2006
    上传时间: 2010-01-11 02:46:28 (UTC+8)
    摘要: 本論文合成一系列兒茶酚1,2-雙加氧酶之功能性模型鐵(III)錯合物錯合物且性質由X-ray單晶繞射儀、UV-Vis光譜、元素分析儀及電化學方法來分析。
    酵素-受質型錯合物及配位基:
    (1) [Fe(L1)(C6Br4O2)]
    (2) [Fe(L1)(C6Cl4O2)]
    (3) [Fe(L2)(C6Cl4O2)]
    (4) [Fe(L3)(C6Cl4O2)]
    (5) [Fe(L4)(C6Cl4O2)]

    L1: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-phenol
    L2: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-5-bromo-phenol
    L3: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-4,6-methoxy-phenol
    L4: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-3-methoxy-phenol
    加入四種不同的兒茶酚陰離子tetrabromocatechol(TBC), tetrachlorocatechol(TCC), catechol(HC),和3,5-di-tert-butylcatechol(3,5-DTBC)與[Fe(L1~4)Cl2]反應，可藉由電子吸收光譜發現兩個新生成兒茶酚到鐵(III)的電子轉移，根據吸收位置與路易士酸性的關係可發現，路易士酸性越強的錯合物[Fe(L2) 3,5-DTBC]有較佳的兒茶酚1,2-雙加氧霉的催化反應性。
    A seiries of iron(III) complexes as funtionl model compounds for catechol 1,2-dioxygenases (intradiol cleavage) were synthesized and characterized by X-ray
    single crystal diffraction, UV-Vis spectroscopy, element analyzer, and electronchemical analysises.Enzyme-substrate complexes and ligands:
    (1) [Fe(L1)(C6Br4O2)]
    (2) [Fe(L1)(C6Cl4O2)]
    (3) [Fe(L2)(C6Cl4O2)]
    (4) [Fe(L3)(C6Cl4O2)]
    (5) [Fe(L4)(C6Cl4O2)]
    L1: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-phenol
    L2: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-5-bromo-phenol
    L3: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-4,6-methoxy-phenol
    L4: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-3-methoxy-phenol
    Catechol 1,2-dioxygenase reactivity has been performed by electronic spectrum in methanol/acetonitrile solutions. The solutions are contained [Fe(L1~4)Cl2] with catecholate anions of tetrabromocatechol(TBC), tetrachlorocatechol(TCC),catechol(HC), and 3,5-di-tert-butylcatechol(3,5-DTBC). The results show that the high lewis acidity iron(III) complexes [Fe(L2) 3,5-DTBC] exhibits the higher catechol 1,2-dioxygenase reactivity.
    显示于类别:[化學學系暨研究所] 學位論文

    文件中的档案:

    档案 大小格式浏览次数
    0KbUnknown326检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈