內雙羥雙加氧酶模型具兒茶酚酶活性之鐵(III)錯合物研究

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题名:	內雙羥雙加氧酶模型具兒茶酚酶活性之鐵(III)錯合物研究
其它题名:	Studies on intradiol dioxygenase model with catecholase activity of iron(III) complexes
作者:	羅順益;Lo, Shun-i
贡献者:	淡江大學化學學系碩士班魏和祥;Wei, Ho-hsiang
关键词:	內雙羥雙加氧酶模型;鐵(III)錯合物;兒茶酚酶活性;X-ray結構;EPR光譜;Intradiol Dioxygenase Model;Iron(III) complexes;Catecholase Activity;X-ray structure;EPR spectrum
日期:	2008
上传时间:	2010-01-11 02:34:13 (UTC+8)
摘要:	本論文合成一系列內雙羥雙加氧酶模型具兒茶酚酶活性之鐵(III)錯合物且性質由X-ray單晶繞射儀、UV-Vis光譜、元素分析儀及電化學方法來分析。酵素-受質型錯合物及配位基: (1) [Fe(L1)(C6Br4O2)] (2) [Fe(L2)(C6Cl4O2)]2 (3) [Fe(L3)(C6Br4O2)(CH3OH)2] (4) [Fe(L4)(C6Br4O2)] (5) [Fe(L5)(C6Cl4O2)(CH3CN)] L1: 2-((E)-(2-(2-aminoethylamino)ethylimino)methyl)-4-chloro-phenol L2: 4-((E)-(2-(2-aminoethylamino)ethylimino)methyl)-benzene-1,3-diol L3: 2-((E)-(2-(2-aminoethylamino)ethylimino)methyl)-6-ethoxy-phenol L4: 2-((E)-(3-(3-aminopropylamino)propylimino)methyl)-4-bromo-phenol L5: 2-((E)-(3-(3-aminopropylamino)propylimino)methyl)-4,6-dibromo-phenol 加入兒茶酚陰離子3,5-di-tert-butylcatechol(3,5-DTBC)與[Fe(L1~5)Cl2]反應，可藉由UV-Vis光譜測量，根據其吸收位置(λ＝400nm)可發現有Diquinone的生成，表示內雙羥雙加氧酶模型的鐵(III)錯合物具有兒茶酚酶活性，且路易士酸性越強的錯合物具有較佳的兒茶酚酶催化反應性。從電化學的分析中，也能得到相同之結果。 A seiries Intradiol Dioxygenase Model of iron(III) complexes as funtionl model compounds for Catecholase Activity were synthesized and characterized by X-ray single crystal diffraction, UV-Vis spectroscopy, element analyzer, and electronchemical analysises. Enzyme-substrate complexes and ligands: (1) [Fe(L1)(C6Br4O2)] (2) [Fe(L2)(C6Cl4O2)]2 (3) [Fe(L3)(C6Br4O2)(CH3OH)2] (4) [Fe(L4)(C6Br4O2)] (5) [Fe(L5)(C6Cl4O2)(CH3CN)] L1: 2-((E)-(2-(2-aminoethylamino)ethylimino)methyl)-4-chloro-phenol L2: 4-((E)-(2-(2-aminoethylamino)ethylimino)methyl)-benzene-1,3-diol L3: 2-((E)-(2-(2-aminoethylamino)ethylimino)methyl)-6-ethoxy-phenol L4: 2-((E)-(3-(3-aminopropylamino)propylimino)methyl)-4-bromo-phenol L5: 2-((E)-(3-(3-aminopropylamino)propylimino)methyl)-4,6-dibromo-phenol Intradiol Dioxygenase Model iron(III) complexes with Catecholase Activity have been performed by UV-Vis spectrum in DMF solutions.The solutions are contained [Fe(L1~5)Cl2] which reacted with catecholate anions of 3,5-di-tert-butylcatechol(3,5-DTBC). The results show that the high lewis acidity of iron(III) complexes exhibits the higher Catecholase reactivity.The analytical results of electrical chemistry have the same as Catecholase reactivity.
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