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    题名: On the Long-Term Fitness of Cells in Periodically Switching Environments
    作者: Pang, Ning-ning;曾文哲;Tzeng, Wen-jer
    贡献者: 淡江大學物理學系
    关键词: Fitness;Biological switch;Population biology;Evolution;Bifurcation
    日期: 2008-01
    上传时间: 2010-08-10 09:47:27 (UTC+8)
    出版者: New York: Springer New York LLC
    摘要: Because all the cell populations are capable of making switches between different genetic expression states in response to the environmental change, Thattai and van Oudenaarden (Genetics 167, 523–530, 2004) have raised a very interesting question: In a constantly fluctuating environment, which type of cell population (heterogeneous or homogeneous) is fitter in the long term? This problem is very important to development and evolution biology. We thus take an extensive analysis about how the cell population evolves in a periodically switching environment either with symmetrical time-span or asymmetrical time-span. A complete picture of the phase diagrams for both cases is obtained. Furthermore, we find that the systems with time-dependent cellular transitions all collapse to the same set of dynamical equations with the modified parameters. Furthermore, we also explain in detail how the fitness problem bears much resemblance to the phenomenon, stochastic resonance, in physical sciences. Our results could be helpful for the biologists to design artificial evolution experiments and unveil the mystery of development and evolution.
    關聯: Bulletin of Mathematical Biology 70(1), pp.210-235
    DOI: 10.1007/s11538-007-9250-9
    显示于类别:[物理學系暨研究所] 期刊論文

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