B- to S-form transition in double-stranded DNA with basepair interactions

淡江大學機構典藏 > 理學院 > 物理學系暨研究所 > 期刊論文 > Item 987654321/27710

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題名:	B- to S-form transition in double-stranded DNA with basepair interactions
作者:	Lai, Pik-yin;周子聰;Zhou, Zi-cong
貢獻者:	淡江大學物理學系
關鍵詞:	Biopolymer;DNA
日期:	2003-04-01
上傳時間:	2009-12-31 10:39:13 (UTC+8)
出版者:	Elsevier
摘要:	When a DNA in its nature double-helical state is stretched by an external force, its length undergoes a sharp extension from the B-form to the 1.7 times elongated S-form. This phenomenon is investigated in the framework of a model of a double-stranded with basepair interactions and bending. Shape equations governing the structure of the DNA under external forces and torques are derived using a classical mechanical approach. The first-order nature of the B- to S-form transition is revealed clearly in terms of an effective potential with a barrier separating these two states. All the structural properties of the DNA in both forms can be calculated in detail. The configurations of the double strands, relative extension, amount of self-untwisting and the threshold stretching force of the DNA under stretched are obtained and compare well with experimental observations.
關聯:	Physica A: Statistical Mechanics and its Applications 321(1-2), pp.170-180
DOI:	10.1016/S0378-4371(02)01776-4
顯示於類別:	[物理學系暨研究所] 期刊論文

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