A category of substances for inflicting in a biomolecular mechanism the conformation breakdown of microbes into biological components is disclosed. A substance of the category has a chemical composition of hydrophobic nature having bonded to at least one structural point of its composition a hydrophilic functional group. A multiplicity of molecules of the substance inflicts the microbe breakdown by being adsorbed to the microbial surface of the target microbe and assembled into aggregates. The substance molecules' aggregates at close proximity to the microbial surface exert adsorptive interaction forces to nearby ones of the microbe biological components. The forces exerted are significant enough to compete with the absorptive interaction forces among the biological components and thereby disrupts the conformation, breaks out of structural binding equilibrium among the biological components, and results in the breakdown and denaturation of the microbe.