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    題名: Apoptosis of human melanoma cells induced by the novel compounds propolin A and propolin B from Taiwenese propolis
    作者: 吳嘉麗;Wu, Chia-li;Chen, Chia-nan;Lin, Jen-kun
    貢獻者: 淡江大學化學學系
    關鍵詞: Propolin A;Propolin B;Taiwanese propolis;Apoptosis;Xanthine oxidase;Human melanoma cells
    日期: 2007-01-08
    上傳時間: 2009-12-01 09:00:33 (UTC+8)
    出版者: Elsevier Ireland
    摘要: We recently demonstrated that two new prenylflavanones, propolin A and propolin B, isolated and characterized from Taiwanese propolis, induced cytotoxicity effect in human melanoma A2058 cells and shows a strong capability to scavenge free radicals. In this study, propolin A effectively induced a cytotoxic effect on five different cancer cell lines. Similar results were obtained for propolin B. DNA flow cytometric analysis and DNA fragmentation ladder indicated that propolin A and propolin B actively induced apoptosis in A2058 cells. To address the mechanism of the apoptosis effect of propolin A and propolin B, we evaluated the apoptosis-related proteins in A2058 cells. The levels of procaspase-8, Bid, procaspase-3, DFF45, and PARP were decreased in dose- and time course-dependent manners. Furthermore, also found propolin A and propolin B was capable of releasing cytochrome c from mitochondria to cytosol. The findings suggest that propolin A and propolin B may activate a mitochondria-mediated apoptosis pathway. On the other hand, our data show that propolin B inhibitied xanthine oxidase activity more efficiently than propolin A or CAPE. However, CAPE suppressed ROS-induced DNA strand breakage more efficiently than propolin A or propolin B. All these results indicated that propolin A and propolin B may trigger apoptosis of A2058 cells through mitochondria-dependent pathways and also shown that propolin A and propolin B were strong antioxidants.
    關聯: Cancer Letters 245(1-2), pp.218-231
    DOI: 10.1016/j.canlet.2006.01.016
    顯示於類別:[化學學系暨研究所] 期刊論文

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