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    題名: Antitumor agents. CII. hinokiflavone, a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavanoids
    作者: Lin, Y. M.;陳發清;Chen, F. C.;Lee, K. H.
    貢獻者: 淡江大學化學學系
    日期: 1989
    上傳時間: 2009-12-01 09:00:30 (UTC+8)
    出版者: Stuttgart: Georg Thieme Verlag
    摘要: Hinokiflavone (1) was isolated as the cytotoxic principle from the drupes of Rhus succedanea L. A comparison of the cytotoxicity of 1 and other related biflavonoids, including amentoflavone (2), robustaflavone (3), agathisflavone (4), rhusflavone (5), rhusflavanone (6) and its hexaacetate (7), succedaneaflavanone (8) and its hexaacetate (9), cupressuflavone (10), neorhusflavanone (11), volkensiflavone (12) and its hexamethyl ether (13), spicataside (14) and its nonaacetate (15), morelloflavone (16) and its heptaacetate (17) and heptamethyl ether (18), GB-1a (19) and its hexamethyl ether (20) and 7″-O-β-glucoside (21), and GB-2a (22), indicates that an ether linkage between two units of apigenin as seen in 1 is structurally required for significant cytotoxicity. Compounds 13 and 20 also demonstrated significant cytotoxicity.
    關聯: Planta medica 55(2), pp.166-168
    DOI: 10.1055/s-2006-961914
    顯示於類別:[化學學系暨研究所] 期刊論文

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