Antiplatelet effect of marchantinquinone, isolated from reboulia hemisphaerica, in rabbit-washed platelets

doi:10.1211/0022357001773913

機構典藏 > College of Sciences > Graduate Institute & Department of Chemistry > Journal Article > Item 987654321/25557

Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/25557

Title:	Antiplatelet effect of marchantinquinone, isolated from reboulia hemisphaerica, in rabbit-washed platelets
Authors:	Liao, C. H.;Ko, F. N.;吳嘉麗;Wu, Chia-li;Teng, Che-ming
Contributors:	淡江大學化學學系
Date:	2000-03
Issue Date:	2009-12-01 09:00:23 (UTC+8)
Publisher:	Pharmaceutical Press
Abstract:	Platelet activation is involved in serious pathological situations, including atherosclerosis and restenosis. It is important to find efficient antiplatelet medicines to prevent fatal thrombous formation during the course of these diseases. Marchantinquinone, a natural compound isolated from Reboulia hemisphaerica, inhibited platelet aggregation and ATP release stimulated by thrombin (0.1 units mL(-1)), platelet-activating factor (PAF; 2 ng mL(-1)), collagen (10 microg mL(-1)), arachidonic acid (100 microM), or U46619 (1 microM) in rabbit washed platelets. The IC50 values of marchantinquinone on the inhibition of platelet aggregation induced by these five agonists were 62.0 +/- 9.0, 86.0 +/- 7.8, 13.6 +/- 4.7, 20.9 +/- 3.1 and 13.4 +/- 5.3 microM, respectively. Marchantinquinone inhibited thromboxane B2 (TxB2) formation induced by thrombin, PAF or collagen. However, marchantinquinone did not inhibit TxB2 formation induced by arachidonic acid, indicating that marchantinquinone did not affect the activity of cyclooxygenase and thromboxane synthase. Marchantinquinone did inhibit the rising intracellular Ca2+ concentration stimulated by the five platelet-aggregation inducers. The formation of inositol monophosphate induced by thrombin was inhibited by marchantinquinone. Platelet cAMP and cGMP levels were unchanged by marchantinquinone. The results indicate that marchantinquinone exerts antiplatelet effects by inhibiting phosphoinositide turnover.
Relation:	Journal of pharmacy and pharmacology 52(3), pp.353-359
DOI:	10.1211/0022357001773913
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

Files in This Item:

File	Description	Size	Format
Antiplatelet effect of marchantinquinone, isolated from reboulia hemisphaerica, in rabbit-washed platelets.pdf		1484Kb	Adobe PDF	2	View/Open
index.html		0Kb	HTML	182	View/Open

Loading...