Synthesis of β-Amino Esters by Regioselective Amination of Allyl Bromides with Aryl and Alkyl Amines

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/25305

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题名:	Synthesis of β-Amino Esters by Regioselective Amination of Allyl Bromides with Aryl and Alkyl Amines
作者:	Lee, Adam Shih-yuan;Chen, Hung-Yang;Patkar, Laxmikant N.;Ueng, Shau-hua;Lin, Chun-cheng
贡献者:	淡江大學化學學系
关键词:	β-amino ester;amination;regioselectivity;α-methylene β-lactam;allyl bromide
日期:	2005-08
上传时间:	2009-12-01
出版者:	Stuttgart: Georg Thieme Verlag
摘要:	One of the two possible regioisomers can be exclusively formed by combining a suitable solvent and a specific amount of triethylamine as a base during the amination of allyl bromide 5. The S(N)2' product 7 was produced using dichloromethane as a solvent and triethylamine (7 equiv) as base; S(N)2 product 6 was predominantly generated in hexane with 0.5 equivalents of triethylamine. Furthermore, a new reaction condition for the efficient cyclization of 7 to yield alpha-methylene beta-lactam 8 using Sn[N(TMS)(2)](2) as a reagent, is disclosed.
關聯:	Synlett 2005(13), pp.2035-2038
DOI:	10.1055/s-2005-871934
显示于类别:	[化學學系暨研究所] 期刊論文

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