Synthesis of β-Amino and β-Methoxy Ketones by Lewis Acids Promoted β-Substitution Reactions of β,γ-Unsaturated Ketones

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/25304

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题名:	Synthesis of β-Amino and β-Methoxy Ketones by Lewis Acids Promoted β-Substitution Reactions of β,γ-Unsaturated Ketones
作者:	Lee, Adam Shih-yuan;Wang, Shu-huei;Chang, Yu-ting;Chu, Shu-fang
贡献者:	淡江大學化學學系
关键词:	β,γ-unsaturated ketone;β-amino ketone;β-methoxy ketone;α,β-unsaturated ketone;1,4-addition reaction
日期:	2003-12
上传时间:	2009-12-01
出版者:	Stuttgart: Georg Thieme Verlag
摘要:	A reaction mixture of β,γ-unsaturated ketone and BF3·OEt2 in CH3OH was stirred at room temperature and β-methoxy ketone was produced in high yield. The β-amino ketone was obtained as the major product from a reaction mixture of β,γ-unsaturated ketone, AlCl3 and Ts-NH2 in CH2Cl2 at room temperature. This Lewis acid promoted β-substitution reaction mechanism was proposed as that the process occurred via in situ isomerization of β,γ-unsaturated ketone to α,β-unsaturated ketone followed by the 1,4-addition reaction.
關聯:	Synlett 2003(15), pp.2359-2363
显示于类别:	[化學學系暨研究所] 期刊論文

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