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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/25302

    Title: Synthesis of a New Family of Aminocyclitols from D-(-)-Quinic acid
    Authors: Shih, Tzenge-lien;Li, Heng-Yi;Ke, Ming-Shin;Kuo, Wei-Shen
    Contributors: 淡江大學化學學系
    Date: 2008-01
    Issue Date: 2009-12-01
    Publisher: Philadelphia: Taylor & Francis Inc.
    Abstract: In continuation of our interest in the synthesis of glycosidase inhibitors, we report herein an efficient synthesis of three new polyhydroxylated amino cyclohexane derivatives (aminocyclitols) that may potentially possess important biological activities. The key step involved the highly stereoselective dihydroxylation of protected azido cyclohexene derivatives 5, 9, and 15, which were easily red from D-(-)-quinic acid. The subsequent hydrogenation step was conducted under acidic conditions to provide the target molecules in an efficient manner with high overall yields.
    Relation: Synthetic Communications 38(23), pp.4139-4149
    DOI: 10.1080/00397910802281429
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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