Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/25277

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题名:	Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy
作者:	李世元;Lee, Adam Shih-yuan;Lin, Shiming;Lee, Chih-kung;Kao, Chuan-liang;Lin, Chii-wann;Wang, An-bang;Hsu, Su-ming;Huang, Long-sun
贡献者:	淡江大學化學學系
日期:	2005-12-01
上传时间:	2009-12-01
出版者:	Blackwell
摘要:	Atomic force microscopy has been used to probe the surface nanostructures of severe acute respiratory syndrome coronavirus (SARS-CoV). Single crown-like virion was directly visualized and quantitative measurements of the dimensions for the structural proteins were provided. A corona of large, distinctive spikes in the envelope was measured after treatment with hydroxyoctanoic acid. High-resolution images revealed that the surface of each single SARS-CoV was surrounded with at least 15 spherical spikes having a diameter of 7.29 +/- 0.73 nm, which is in close agreement with that of S glycoproteins earlier predicted through the genomes of SARS-CoV. This study represents the first direct characterization of the surface ultrastructures of SARS-CoV particles at the nanometre scale and offers new prospects for mapping viral surface properties.
關聯:	Cellular Microbiology 7(12), pp. 1763-1770
DOI:	10.1111/j.1462-5822.2005.00593.x
显示于类别:	[化學學系暨研究所] 期刊論文

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