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    題名: Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy
    作者: 李世元;Lee, Adam Shih-yuan;Lin, Shiming;Lee, Chih-kung;Kao, Chuan-liang;Lin, Chii-wann;Wang, An-bang;Hsu, Su-ming;Huang, Long-sun
    貢獻者: 淡江大學化學學系
    日期: 2005-12-01
    上傳時間: 2009-12-01
    出版者: Blackwell
    摘要: Atomic force microscopy has been used to probe the surface nanostructures of severe acute respiratory syndrome coronavirus (SARS-CoV). Single crown-like virion was directly visualized and quantitative measurements of the dimensions for the structural proteins were provided. A corona of large, distinctive spikes in the envelope was measured after treatment with hydroxyoctanoic acid. High-resolution images revealed that the surface of each single SARS-CoV was surrounded with at least 15 spherical spikes having a diameter of 7.29 +/- 0.73 nm, which is in close agreement with that of S glycoproteins earlier predicted through the genomes of SARS-CoV. This study represents the first direct characterization of the surface ultrastructures of SARS-CoV particles at the nanometre scale and offers new prospects for mapping viral surface properties.
    關聯: Cellular Microbiology 7(12), pp. 1763-1770
    DOI: 10.1111/j.1462-5822.2005.00593.x
    顯示於類別:[化學學系暨研究所] 期刊論文


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