The 1-isoprpylaminopropan-2-ol group can be selectively converted to a cyclic, 2,4-dichlorobenzeneboronate derivative with good gas chromatographic properties. The reaction does not occur significantly in the solution phase under normal experimental conditions, but a quantitative yield of derivative can be formed in an on-column reaction at the point of injection by either direct reaction with the boronic acid or by transboronation. The transboronation reaction using the 2,4-dichlorobenzeneboronate derivative of catchol as teh derivatizing reagent was found to be superior to teh use of other reagents for derivatizing the 1-isopropylaminopropan-2-ol group.
